How It Works
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AMPK Activation: MOTS-c activates AMP-activated protein kinase (AMPK), a key energy sensor that enhances fat oxidation and glucose uptake.
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Improved Insulin Sensitivity: Enhances glucose utilization in muscle cells and improves insulin signaling.
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Mitochondrial Support: Boosts mitochondrial function and biogenesis, improving energy output and metabolic health.
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Exercise Mimetic: Acts like a cellular “exercise signal,” promoting endurance and fat burning even in sedentary states.
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Stress Adaptation: Supports metabolic flexibility and adaptation to physical or oxidative stress.
How to Use It
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Dosage:
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5–15 mg per day, typically in research settings.
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Most commonly used at 10 mg/day, 5 days per week.
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Frequency:
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Daily subcutaneous injection, ideally in the morning or pre-workout.
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Cycle Length:
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Cycles typically run 4 to 8 weeks, though some use it longer for longevity or fat loss goals.
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Stacking:
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Commonly paired with GHK-Cu, BPC-157, AOD-9604, or L-carnitine for enhanced fat metabolism and recovery.
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Can also stack well with GLP-1 agonists or cardio regimens during cutting phases.
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Post-Cycle Consideration:
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None required. It does not impact endogenous hormone production.
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Administration:
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Subcutaneous injection (abdominal fat or alternate site).
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Positive and Negative Side Effects
Positive Side Effects
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Increased fat loss and energy expenditure
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Improved insulin sensitivity and glucose regulation
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Enhanced endurance and physical performance
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Potential anti-aging effects via mitochondrial support
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Supports recovery and metabolic flexibility
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May help in weight management during caloric restriction
Negative Side Effects
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Minimal to no reported side effects in studies
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Rare cases of mild fatigue, headache, or irritation at injection site
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As a mitochondrial peptide, long-term human research is still ongoing
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Not recommended during pregnancy or for individuals with active cancer
Product Disclaimer
We always suggest to do your own research before making a decision on which formulas are best for you. Listening to others may put you in danger, and we always recommend for newcomers to make themselves informed of all the benefits, and side effects.
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